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Santiago Ramón García
Micobacterial Genetics Group. Dep. Microbiology. Univ. Zaragoza
University of Zaragoza
Doctor en Ciencias
Discovery and development of new antimicrobials
Mechanisms of intrinsic & acquired drug resistance
New uses for old drugs, synergistic drug repurposing
Nanoparticle-based antimicrobial therapies
Molecular microbiology: genetics, transcriptomics, proteomics
Drug profiling: susceptibility in vitro and intracellular, efflux & uptake
Animal models of TB infection for single and combination drug testing
Management & dissemination
Facilities and techniques:
In vitro and in vivo BSL3.
Clinical microbiology: diversity panel ca. 3000 isolates Mtb
PK/PD: hollow fiber, time lapse (in progress)
Antimicrobial Resistance; Drug Discovery and Development; Antibiotics; Tuberculosis; Neglected Diseases; Non-Tuberculosis Mycobacteria
Grupo de Genética de Micobacterias
Repurposing clinically approved cephalosporins for tuberculosis therapy.
Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains.
Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen.