A New Access to 4H-Quinolizines form 2-Vinylpyridine and Alkynes Promoted by Rhodium-N-Heterocyclic-Carbene Catalysts

Autores: Ramón Azpíroz, Andrea Di Giuseppe, Ricardo Castarlenas, Jesús J. Pérez-Torrente y Luis Oro Ref. revista: Chemistry A European Journal, 19, 3812-3816 (2013)

Rh[BOND]NHC catalysts promote a new access to 4 H-quinolizine species from 2-vinylpyridine and terminal and internal alkynes through C[BOND]H activation and C[BOND]C coupling reactions (see figure). N-Bridgehead heterocycle formation is favored for internal- over terminal-substituted butadienylpyridine derivatives in a thermal 6π-electrocyclization process.