Organocatalytic Conjugate Addition of Formaldehyde N,N-dialkylhydrazones to beta,gamma-Unsaturated alfa-Keto Esters
Raquel P. Herrera, David Monge, Eloisa Martín-Zamora, Rosario Fernández, José M. Lassaletta. Organocatalytic Conjugate Addition of Formaldehyde N,N-dialkylhydrazones to beta,gamma-Unsaturated alfa-Keto Esters. Org. Lett.. 2007, Vol. 01/09/07, p. 3303-2007.
<p>(1S,2R)-1-Aminoindan-2-ol-derived thioureas behave as efficient H-bonding organocatalysts for the nucleophilic conjugate addition of formaldehyde hydrazones to b,g-unsaturated a-keto esters as enoate surrogates, affording the corresponding adducts in good yields and enantioselectivities.</p>
<p>(1S,2R)-1-Aminoindan-2-ol-derived thioureas behave as efficient H-bonding organocatalysts for the nucleophilic conjugate addition of formaldehyde hydrazones to b,g-unsaturated a-keto esters as enoate surrogates, affording the corresponding adducts in good yields and enantioselectivities.</p>