Finding Common Molecular Mechanisms in Neurodegeneration

Neuropathological hallmarks of neurodegenerative diseases such as Alzheimer (AD) or Frontotemporal Dementia (FTD) in the cerebral cortex are well- known since long ago. However, the ultimate molecular mechanisms and genetic background leading to disease remain largely unknown. Thus, we are lacking both clinical biomarkers for early diagnosis and drugs that significantly alter the course of the neuronal death. Progranulin (PGRN), a secreted growth factor, is a key regulator of inflammation and is genetically linked to two both devastating neurodegenerative diseases (AD and FTD). Our project seeks to elucidate the common regulatory mechanisms underlying FTD and AD pathogenesis and identify candidate biomarkers along with new therapeutic targets.

Acronym: 
MOMENEU
Author: 
Schoorlemmer , Jon
Principal researcher: 
Juan Cabello
Managing entity: 
Otros
Scope: 
Internacional
Entidades participantes: 
CIBIR/Fundación Rioja Salud
Navarra Biomed
Université Paul Sabatier, Toulouse, Francia
BioCruces Health Research Institute
Instituto Aragones de Ciencias de la Salud IACS
Number of researchers: 
5
Start date: 
03/2017
End date: 
10/2018
Entidad financiadora
Financing entity: 
Refbio II Network
Call: 
Collaborative projects 2017
Presupuesto
Total budget: 
88.000€