The closed conformation of the LDL receptor is destabilized by the low Ca++ concentration but favored by the high Mg++ concentration in the endosome.

Juan Martínez-Oliván, Xabier Arias-Moreno, Ramón Hurtado-Guerrero, José Alberto Carrodeguas, Laura Miguel, Alberto Marina, Pierpaolo Bruscolini and Javier Sancho*. The closed conformation of the LDL receptor is destabilized by the low Ca++ concentration but favored by the high Mg++ concentration in the endosome. FEBS Letters, 30;589(23):3534-40. doi: 10.1016/j.febslet.2015.10.014, 2015.