Biocatalytic Synthesis of Chiral Amines Using Oxidoreductases
Sebastian C. Cosgrove, Jeremy I. Ramsden, Juan Mangas-Sanchez and Nicholas J.
Turner, Biocatalytic Synthesis of Chiral Amines Using Oxidoreductases in Methodologies in Amine Synthesis: Challenges and Applications 2021 Wiley-VCH Pages 243-283
In the past two decades, the development of more effective tools for enzyme discovery and engineering has greatly expanded the biocatalytic toolbox for chiral amine synthesis. Currently, several classes of enzymes are available for this task, and some of
them, such as transaminases (TAs), are now widely used in process chemistry for the manufacture of a broad range of chiral amines. Lipases are also widely used and, similarly, they have been thoroughly reviewed. The focus of this chapter is oxidoreductases, enzymes that use nicotinamide or flavin cofactors to perform redox chemistry, which represent an exciting and a promising field of research in the coming years
In the past two decades, the development of more effective tools for enzyme discovery and engineering has greatly expanded the biocatalytic toolbox for chiral amine synthesis. Currently, several classes of enzymes are available for this task, and some of
them, such as transaminases (TAs), are now widely used in process chemistry for the manufacture of a broad range of chiral amines. Lipases are also widely used and, similarly, they have been thoroughly reviewed. The focus of this chapter is oxidoreductases, enzymes that use nicotinamide or flavin cofactors to perform redox chemistry, which represent an exciting and a promising field of research in the coming years