.

Julián Pardo Jimeno

Centro de Investigación Biomedica de Aragon

University of Zaragoza

Head of Immunotherapy, Inflammation and Cancer group

Education: 

Immunology

Research interests: 

Tc, NK cells and cancer immunosurveillance

Molecular mechanisms of cytotoxicity induced by Tc/NK cells on cancer cells.

Cancer immunotherapy using adoptive NK cell transfer.

Tc and NK cells in infectious, inflammatory and autoimmune disorders

Molecular mechanisms of inflammation induced by perforin/granzymes.

Facilities and techniques: 

Mouse models (cancer, infection, inflammation, autoimmunity)

GMP cell production

Nanotoxicology and Immunotoxicology

Relevant publications: 

Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation.

Tumour cell death induced by cytotoxic T cells is immunogenic and primes caspase-3 dependent spread immunity against endogenous tumour antigens